Missouri vs. Alabama: Odds, Predictions, Player Props, and a Best Bet for Saturday, October 26

If someone told you before the season that the No. 21 ranked Missouri Tigers (6-1) would have a better record than the No. 15 ranked Alabama Crimson Tide (5-2) when these two teams met, you’d probably called them out for talking foolishness.

Missouri being 6-1 isn’t the crazy part, however. The Tigers have handily defeated every team it should have and won against two teams SEC teams that play better than their records indicate. For this game, Missouri is expected to be without star quarterback Brady Cook as the Tigers listed him as doubtful on Wednesday.

Alabama sitting at 5-2 may sound crazy, but Vanderbilt – who beat them earlier this month – is a solid football team and Tennessee is a Top 10 program. What is crazy, however, is how poorly Alabama’s defense has played without head coach Nick Saban roaming the sidelines.

Will the Tigers make this a game, or will Alabama right the ship and roll Missouri? We’ll cover that and our three top player prop bets below.

Jalen Milroe (BAMA) OVER 240.5 Passing Yards

After leading his team to victory over Georiga, Crimson Tide quarterback Jalen Milroe was being hyped for the Heisman. Since that game, he’s thrown more interceptions (five) than touchdowns (three) as his team has lost two of those three games.

He’s also thrown for over 240 yards just once during that span, achieving that in the game against Vanderbilt earlier this month. With the Crimson Tide facing a stout Missouri defense, he’ll need to post big numbers for Alabama to win this contest. Expect him to surpass 241 yards through the air on Saturday to cover this prop bet.

Theo Wease Jr. (MIZZOU) OVER 44.5 Receiving Yards

Missouri’s Cook has been a big part of the Tigers’ rise over the past two seasons. This year, the 6-foot-2 senior quarterback has thrown for 1,545 yards and seven touchdowns in parts of seven games. He’ll potentially be replaced on Saturday by transfer quarterback Drew Pyne.

Pyne has played at three schools over the past five seasons. After a three-year stint at Notre Dame, Pyne played sparingly at Arizona State before heading to Missouri in 2024. As a Tiger, he’s completed 67.4 percent of his passes for 206 yards in relief of Cook.

Regardless of who is quarterbacking the offense, senior wide receiver Theo Wease Jr. will be their top target. The 6-foot-2 athlete has caught 35 passes for 463 yards and one touchdown this season, and he’ll eclipse 45 yards against Alabama for the seventh consecutive game.

C.J. Dippre (BAMA) UNDER 20.5 Receiving Yards

Under Alabama’s new head coach Kalen DeBoer, the Crimson Tide has relied less on tight ends this season than in years past. Senior C.J. Dippre is the prime example of that. Nearly a third of his season yardage total (142) was on one pass against Vanderbilt – a 46-yard reception.

Including that Commodores contest, Dippre has three outings where he caught at least 20 yards or more in a single game. It’s hard to expect the Crimson Tide will get him involved enough on Saturday to cover this prop bet.

Best Bet: Missouri (+17.5)

The Tigers are a scrappy bunch, and outside of their loss to Texas A&M, looked strong in spurts in every outing. Assuming the Tigers will not be competitive against Alabama seems a little crazy.

Yes, Cook isn’t supposed to play, but Alabama’s defense has been porous this season. Expect Missouri to take advantage of that and find ways to score and keep this game close until the final buzzer sounds.