Seahawks vs Titans Preseason Week 2 Preview: Odds, Spread, and Best Bet for Sunday Night

The defending Super Bowl champion Seattle Seahawks head to Nashville for a preseason primetime tilt against the Tennessee Titans on Sunday night, with kickoff at Nissan Stadium set for 8 p.m. ET on FOX. It’s the second preseason game for both clubs, and while the stakes are strictly evaluative rather than playoff-caliber, the betting market and roster battles still give this one plenty to watch. Seattle is coming off a rough 17-7 loss to Dallas in its preseason opener, while Tennessee opened with a 19-13 win over San Francisco behind a heavy dose of the run game.

Why Vegas Has the Titans Favored Over the Champs

Despite Seattle being the reigning Super Bowl champion on paper, oddsmakers have installed Tennessee as a 4.5-point favorite, with the total sitting between 37.5 and 38 points depending on the book. The moneyline reflects the same lean: Titans -220 to -205, Seahawks +170 to +180. That’s a notable market signal for a team many expected to be a bottom-tier outfit this season.

The line makes more sense once you consider preseason betting dynamics. Championship rosters typically rest starters and play conservatively in exhibition action, while rebuilding teams like Tennessee are still auditioning roster spots and tend to play backups and bubble players with something to prove. Bettors weighing a DraftKings promo code for this slate should note the line movement carefully given how thin preseason markets can be. The Titans’ run game piled up 167 yards on 31 carries in the opener, and kicker Joey Slye has been automatic, going 4-for-4 on field goals against San Francisco and now 23-of-23 across his last four outings including joint practices.

Seattle’s offense, by contrast, struggled badly in its opener. Quarterback Jalen Milroe finished with just 36 passing yards and 36 rushing yards against Dallas, numbers that won’t move a betting line in the Seahawks’ favor no matter the pedigree hanging in the rafters back in Seattle.

Rookies, Return Timelines, and Practice-Week Buzz

The bigger storylines this week haven’t come from the scoreboard but from the joint practice sessions the two teams held Friday at Vanderbilt Health Football Center. Titans cornerback Alontae Taylor was the headline performer, delivering a highlight-reel pick-six along with multiple pass breakups, marking a sharp turnaround for a Tennessee secondary that struggled in last week’s joint session against San Francisco.

On offense, rookie quarterback Cam Ward has quietly put together an encouraging week of practice, completing 86 of 112 throws (76.7%) across joint sessions after a shaky middle stretch against the 49ers. He did throw a pick-six of his own in Friday’s session, but bounced back to lead a late touchdown drive, continuing the pattern of resilience that’s defined his week. Rookie wide receiver Carnell Tate, Tennessee’s first-round pick, has cooled off after a hot start to camp — he was held without a catch in the preseason opener and again in Friday’s joint practice, a stretch worth monitoring as the roster picture sharpens. Rookie edge rusher Keldric Faulk was one of seven Titans rookies who made his preseason debut in Week 1 and figures to see more run again Sunday.

For Seattle, all eyes will be on rookie running back Jadarian Price, the team’s first-round pick, who is working back from a minor injury and could make his preseason debut Sunday night. Any snaps he gets will be closely watched given his draft pedigree and the Seahawks’ underwhelming offensive opener.

What to Expect With Backups Taking Over

Since this is preseason Week 2 rather than a regular-season primetime showdown, expect both coaching staffs to lean further into evaluation mode. Starters who played limited snaps in Week 1 could see even less action here, or none at all, pushing more of the workload onto players fighting for roster spots. That context matters heavily for anyone eyeing the total — backup-heavy football tends to be sloppier and lower-scoring, which lines up with a number sitting in the high-30s rather than anywhere close to what these two teams would put up in the regular season.

Tennessee’s approach so far this preseason has leaned on the ground game and situational execution rather than explosive plays, and Joey Slye’s perfect kicking streak suggests the Titans are also finding easy points in field-goal range even when drives stall. Seattle will need a cleaner performance from its passing offense than it got in Dallas if it wants to keep this one competitive against a Titans team playing with real confidence after Friday’s joint practice showing.

Sun, Sep 20 • 4:25 PM	Spread	Money	Total
Seattle Seahawks	-4.5 (-115)	-218	O 41.5 (-105)
Arizona Cardinals	+4.5 (-115)	+198	U 41 (-108)

Prediction and Best Bet

Tennessee’s practice-week momentum, its stingy defensive turnaround led by Alontae Taylor, and a Seattle offense still searching for answers all point toward the Titans covering at home. This profiles as another low-scoring, backup-driven preseason contest where Tennessee’s ground game and reliable kicking edge out a Seahawks offense still finding its footing under Jalen Milroe.

• Prediction: Titans 20, Seahawks 13
• Best Bet: Titans -4.5 on the spread

The Titans have shown more cohesion through two weeks of practices and one preseason game than their record suggests they should, while Seattle’s offensive line and passing attack have real questions to answer. Laying the field goal and a bit more with Tennessee at home is the sharper side of this number.