Pirates vs. Yankees Prediction: Can New York’s Pitching Edge Hold Up in Game 2?
The Yankees and Pirates run it back at Yankee Stadium on July 21 with Will Warren facing Bubba Chandler. Here's our full prediction, odds breakdown, and best bet.

The Yankees just took Game 1 of this series behind their bats, and now they’re leaning on a rookie arm with a losing record to close out the middle game against a Pirates team that refuses to go away.
Quick take:
- Pick: Yankees -1.5
- Why: Will Warren has quietly been the Yankees’ most reliable starter, and Pittsburgh’s offense has been unreliable on the road all year
- The number to watch: Bubba Chandler’s 4.77 ERA against a Yankees lineup averaging 4.68 runs per game
New York beat Pittsburgh 8-5 on Monday to open this three-game set at Yankee Stadium, and the Yankees are sitting at 56-44, just 1.5 games back of Tampa Bay in the AL East. The Pirates, meanwhile, are 52-49 and 10.5 games out in the NL Central, but they’ve won 7 of their last 10 heading into this series and are hardly a pushover — Pittsburgh took two of three from Cleveland over the weekend before landing in the Bronx.
This is a classic contender-versus-spoiler matchup. The Yankees need every win they can get to keep pace with Tampa Bay, and the Pirates would love nothing more than to steal a game from a team fighting for its playoff life. Pittsburgh has already shown this month it can hang with quality opponents on the road, and interleague trips like this one give the Pirates a chance to pad their record against a team most of the league is watching closely.
New York’s lineup has been streaky lately, alternating big offensive nights with quiet ones, while Pittsburgh has actually been the more consistent scoring team over the past two weeks. That contrast is part of what makes this particular pitching matchup so interesting — it pits a Yankees staff that’s been arguably the best in the American League against a Pirates offense that has real thump in the middle of the order.
What the Odds Are Saying About This Pitching Mismatch
Books have the Yankees favored at -1.5 on the run line (+136 for Pittsburgh to cover), with the moneyline sitting around -145 for New York and +126 for the Pirates. The total is set at 9, reflecting two lineups that can put up crooked numbers but a pair of shaky-to-solid starters on the mound. Will Warren draws the start for New York, sporting a 7-4 record with a 4.03 ERA and 96 strikeouts over 98.1 innings — quietly one of the more dependable arms in the Yankees rotation this season. Bubba Chandler goes for Pittsburgh at 3-8 with a 4.77 ERA and 85 strikeouts, numbers that explain why the market has installed New York as a clear favorite even in a game the Pirates covered the run line odds slightly better than the moneyline would suggest.
The Numbers Side by Side
| Pirates | Yankees | |
|---|---|---|
| Record | 52-49 | 56-44 |
| Runs/game | 5.26 | 4.68 |
| Team ERA | 4.30 | 3.38 |
| Last 10 games | 7-3 | 6-4 |
Why New York’s Pitching Edge Should Hold Up
The gap that stands out here isn’t the offense — it’s the arms. New York’s 3.38 team ERA is nearly a full run better than Pittsburgh’s 4.30, and that shows up start to start, not just in one good week. Cody Bellinger has been part of the reason New York’s lineup keeps grinding out wins even when the big names go cold; he’s hitting .255 with 11 home runs and 52 RBI on the year and collected two hits in Monday’s series opener against this same Pirates staff.
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New York’s pitching staff owns a 3.38 ERA compared to Pittsburgh’s 4.30 — nearly a full run of separation across 100-plus games.
That run-prevention gap matters more in a game like this than raw offensive firepower does. Pittsburgh actually scores more per game than New York on paper, but Bryan Reynolds and company have to face a Yankees pitching staff that’s been the more consistent unit from April through July. Jazz Chisholm Jr. adds another layer of danger to the New York lineup — 16 homers and 26 stolen bases give the Yankees a game-changing threat even on nights the big bats are quiet.
Pittsburgh’s bullpen has been shakier than its rotation on the road, and that’s the swing factor in a game projected to go over 9 runs.
Bryan Reynolds remains Pittsburgh’s biggest offensive threat and the name most likely to punish a Warren mistake pitch, but the Pirates need more than one bat clicking to hang with a Yankees lineup that has scored in bunches for most of July. New York’s depth — from Bellinger and Chisholm down through the bottom of the order — is exactly the kind of thing that wears down a starter like Chandler over five or six innings, and it’s why the home team carries the edge even in a game that should feature plenty of runs.
Bettors leaning toward New York laying the run line might also shop around a FanDuel promo code before locking in a number, since the moneyline and run-line prices have both moved slightly since Monday’s series opener.
Prediction and Best Bet
Expect the Yankees’ deeper pitching staff to be the difference-maker again. Warren has been steady enough to keep Pittsburgh’s lineup in check for five-plus innings, and New York’s bullpen has the edge late. The Pirates will make it competitive — they always seem to against good teams — but this is New York’s game to lose at home.
| Tue, Sep 15 • 6:41 PM | Spread | Money | Total |
| Milwaukee Brewers | ![]() -1.5 (-125) | ![]() -215 | ![]() O 7.5 (-105) |
| Pittsburgh Pirates | ![]() +1.5 (100) | ![]() +180 | ![]() U 7.5 (-117) |
The pick:
- Prediction: Yankees 6, Pirates 4
- Best Bet: Yankees -1.5
Lay the run line with New York here — the pitching gap is too wide to ignore, and the Yankees need this one more than Pittsburgh does.



